IMPAcTB

Overview
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Web page: https://www.niaid.nih.gov/research/immune-mechanisms-protection-mycobacterium-tuberculosis

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Charles Demurjian

Projects: Hi-IMPAcTB, MIT SRP, MetNet, Endometriosis

Institutions: Massachusetts Institute of Technology

Huiming Ding

Projects: Hi-IMPAcTB, MIT SRP, MetNet

Institutions: Massachusetts Institute of Technology

Stuart Levine

Projects: MIT SRP, Hi-IMPAcTB, MetNet

Institutions: Massachusetts Institute of Technology

https://orcid.org/0000-0001-7363-562X

Douaa Mugahid

Projects: Hi-IMPAcTB

Institutions: Massachusetts Institute of Technology

https://orcid.org/0000-0002-3455-2992

Dikshant Pradhan

Projects: Hi-IMPAcTB, MIT SRP

Institutions: Massachusetts Institute of Technology

Researcher at BioMIcro Center, Data Management and Analysis Core; Massachusetts Institute of Technology

Jake Schissel

Projects: Hi-IMPAcTB, MIT SRP

Institutions: Massachusetts Institute of Technology

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Hi-IMPAcTB

About

This project houses all the publicly available datasets generated by the Hi-IMPAcTB consortium over the course of its 7+ years.

What is Hi-IMPAcTB?

Hi-IMPAcTB is an ambitious endeavor bringing together a team of international, interdisciplinary researchers to improve our understanding of host-pathogen interactions in the context of tuberculosis (TB). Funded by a multi-center contract from the NIH, the long-term goal of the consortium is to enable principled vaccine design by improving ...

Programme: IMPAcTB

Public web page: https://grantome.com/grant/NIH/75N93019C00071-0-9999-1

Organisms: Mus musculus, Homo sapiens, Macaca fascicularis, Macaca mulatta

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Massachusetts Institute of Technology

Country: United States

City: Not specified

Web page: Not specified

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IMPAcTB

Hi-IMPAcTB

No description specified

Submitter: Dikshant Pradhan

Studies: CD8+ lymphocytes are critical for early control of tuberculosis in macaques, Fc-FcγR interactions shift alveolar macrophage metabolism to promote Myc..., Humoral correlates of protection against Mycobacterium tuberculosis foll..., Immune cells in bronchoalveolar lavage fluid of Ugandan adults who resis..., Multimodal profiling of lung granulomas in macaques reveals cellular cor..., Mycobacterium tuberculosis-specific antibodies detect progression to act..., Robust IgM responses following intravenous vaccination with Bacille Calm..., T cell signatures of bacterial control among M. tuberculosis 'resisters'

Assays: All Metadata, Anti-Microbial Assay – Metadata, Antibody-Dependent Cellular Phagocytosis - Data Linked, Antibody-Dependent Cellular Phagocytosis - Data Linked, Antibody-Dependent Cellular Phagocytosis Analysis - Data Linked, Antibody-Dependent NK Cell Activation - Data Linked, Antibody-Dependent NK Cell Activation Analysis - Data Linked, Antibody-Dependent Neutrophil Phagocytosis - Data Linked, Antibody-Dependent Neutrophil Phagocytosis - Data Linked, Antibody-Dependent Neutrophil Phagocytosis Analysis - Data Linked, Bacterial Extraction - Metadata, DNA Extraction - Metadata, Digitally Barcoded Mtb Matrix Analysis - Data Attached, FC Receptor Binding - Data Linked, FC Receptor Binding Analysis - Data Linked, FC Receptor Binding Assay - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Attached, Flow Cytometry Analysis - Data Linked, Flow Cytometry Processing – Data Attached, Flow Cytometry – Data Linked, Functional Assay – Metadata, Immunohistochemistry - Data Linked, Immunohistochemistry – Data Linked, Library Creation – Metadata, Linear Mixed Model - Data Linked, Luminex Assay – Metadata, Luminex Data Processing – Data Attached, NHP Necropsy – Metadata, NHP Tissue Collection – Metadata, PET-CT Scan Analysis – Data Linked, PET-CT Scan – Data Linked, PET/CT Scan - Data Linked, Patient Visit - Metadata, Patient Visit - Metadata, Patient Visit - Metadata, Patient Visit - Metadata, Patient Visit – Metadata, Patient Visit – Metadata, Short Read Sequencing - Data Linked, Single Cell Clustering Analysis – Data Linked, Single Cell Expression Analysis - Data Linked, Single Cell Expression Matrix Analysis – Data Linked, Single Cell Sequencing Analysis – Data Linked, Single Cell Sequencing – Data Linked, Single Cell Sequencing – Data Linked, Tissue Collection - Metadata, Tissue Collection - Metadata, Tissue Collection - Metadata, Tissue Collection - Metadata, Tissue Collection - Metadata, Tissue Extraction – Metadata, Titer Assay - Data Linked, Titer Assay - Data Linked, Titer Assay Analysis - Data Linked

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Created: 14th Jan 2021 at 15:10, Last updated: 18th Oct 2021 at 14:05

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Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guérin vaccination in rhesus macaques

Hi-IMPAcTB

Edward B Irvine, Patricia A Darrah, Shu Wang, Chuangqi Wang, Ryan P McNamara, Mario Roederer, Robert A Seder, Douglas A Lauffenburger, JoAnne L Flynn, Sarah M Fortune, Galit Alter

https://doi.org/10.1101/2023.07.31.551245

Altering the route of Bacille Calmette-Guérin (BCG) immunization from low-dose intradermal vaccination to high-dose intravenous (IV) vaccination resulted in a high level of protection against Mycobacterium tuberculosis ( Mtb ) infection, ...