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4 Publications visible to you, out of a total of 4
Comparison of 432 Pseudomonas strains through integration of genomic, functional, metabolic and expression data.

Abstract (Expand)

Pseudomonas is a highly versatile genus containing species that can be harmful to humans and plants while others are widely used for bioengineering and bioremediation. We analysed 432 sequenced Pseudomonas … strains by integrating results from a large scale functional comparison using protein domains with data from six metabolic models, nearly a thousand transcriptome measurements and four large scale transposon mutagenesis experiments. Through heterogeneous data integration we linked gene essentiality, persistence and expression variability. The pan-genome of Pseudomonas is closed indicating a limited role of horizontal gene transfer in the evolutionary history of this genus. A large fraction of essential genes are highly persistent, still non essential genes represent a considerable fraction of the core-genome. Our results emphasize the power of integrating large scale comparative functional genomics with heterogeneous data for exploring bacterial diversity and versatility.

Authors: J. J. Koehorst, J. C. van Dam, R. G. van Heck, E. Saccenti, V. A. Dos Santos, M. Suarez-Diez, P. J. Schaap

Date Published: 6th Dec 2016

Publication Type: Journal

Engineering an anaerobic metabolic regime in Pseudomonas putida KT2440 for the anoxic biodegradation of 1,3-dichloroprop-1-ene

Abstract

Not specified

Authors: Pablo I. Nikel, Víctor de Lorenzo

Date Published: 2013

Publication Type: Not specified

Reconciliation of Genome-Scale Metabolic Reconstructions for Comparative Systems Analysis

Abstract

Not specified

Authors: Matthew A. Oberhardt, Jacek Puchałka, Vítor A. P. Martins dos Santos, Jason A. Papin

Date Published: 31st Mar 2011

Publication Type: Not specified

In silico genome-scale metabolic analysis of Pseudomonas putida KT2440 for polyhydroxyalkanoate synthesis, degradation of aromatics and anaerobic survival

Abstract

Not specified

Authors: Seung Bum Sohn, Tae Yong Kim, Jong Myoung Park, Sang Yup Lee

Date Published: 1st Jul 2010

Publication Type: Not specified

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