Investigations
What is an Investigation?Filters
nfdi4health Dokumente und (interne) Daten, SOPs, etc., die relevant für das gesamte Konsortium sind
Key activities of TA1 concern the establishment of functional bodies and of the project governance for NFDI4Health.
NFDI4Health task area 2 targets core deficits in medical sciences, i.e. the lack of harmonised standards for data and data quality management in clinical trials, public health surveys, and epidemiological cohorts, as well as the lack of information on and access to relevant standards. By making standards available, TA2 will improve the findability, accessibility and interoperability of existing and novel data bodies. For this purpose, guidelines, standards and policies on data management and ...
Submitter: Martin Golebiewski
Studies: NFDI4Health T2.1: Data management and publication policies, NFDI4Health T2.2: Data and metadata standards and integration, NFDI4Health T2.3: Data quality and data provenance, NFDI4Health T2.4: Standardisation of health data access and interoperabi...
Assays: No Assays
TA3 focusses on the services, service enabling tools, and software that NFDI4Health will provide to the user community. Most services and tools will be based on open source software that has already been developed by the (co-)applicants or by the broader scientific developer community. In close cooperation with TA4 and TA5, use case requirements and community feedback will help to further develop these tools and to foster interoperability of currently fragmented IT solutions for storage of metadata, ...
With its focus on interaction, networking and exchange, task area 4 addresses the overall NFDI4Health Key Objective to support cooperation between clinical research, epidemiological and public health communities. It also provides training and education for the health research community and beyond, focusing on FAIR data principles.
Shared Space on OneDrive: https://onedrive.live.com/?id=4E57D2DCFD31954C%213715&cid=4E57D2DCFD31954C
The main objective of task area 5 of NFDI4Health is to implement or to at least explore the possibilities to implement these infrastructure components in specific use cases which reflect core needs of the scientific community related to health data research. The use cases will address a range of areas which will lay the ground for future expansion for full coverage of the broad range of data collected in health research.
Data protection regulations have to be taken into account on many levels of the infrastructure developed by NFDI4Health. Moreover, the health data managed by NFDI4Health belong to the so-called special categories of personal data, the processing of which is subject to particularly strict data protection requirements. But nevertheless, data protection law contains a variety of regulatory approaches of data processing for scientific research purposes, which are all aimed at a privileged treatment ...
Project to test effects of temperature cycles on expression of Arabidopsis florigen gene FT, and whether these are mediated by temperature-dependent leaf development or temperature-specific FT expression, or both. Re-used and extended Arabidopsis Framework Model v1 to address this question. Led by Hannah Kinmonth-Schultz in Kim and Imaizumi labs, collaborating with Millar lab.
Submitter: Andrew Millar
Here SYSMO-LAB put all there pre-liminary data files or models ordered per person and project
Submitter: Martijn Bekker
Studies: Pre-liminary data from Martijn Bekker, Pyruvate formate-lyase (PFL), allosteric regulation of pyruvate kinase
Assays: Characterization of enzymes involved in butanediol formation, Kinetic behavior of intracellular metabolites of E. faecalis upon a gluc..., Kinetic behavior of intracellular metabolites of L. lactis upon a glucos..., Pyruvate formate-lyase (PFL): literature review, structure analysis and ..., literature values for allosteric regulation of pyruvate kinase
Submitter: Christina Döring
Studies: Effect of pH on the metabolome, Effect of pH on the proteome, Effect of pH upon the transcriptome, Identification of clusters of co-regulated and anti-regulated genes, Modelling the effect of pH on the metabolic shift
Assays: Comparison of the proteome between pH 5.7 (acidogenesis) and pH 4.5 (sol..., Comparison of the transcriptome between pH 5.7 (acidogenesis) and pH 4.5..., Comparison of the transcriptome between pH 5.8 (acidogenesis) and pH 4.5..., Identification of dynamically similar transcript profiles, Steady state study of the effect of gene regulation on yields of end-pro..., Study of the end products of the acidogenesis and solventogenesis pathways, Time-dependent simulations
The objective of this project is an integrated understanding the metabolic, proteomic and genetic network that controls the transition from growth to glucose starvation. This transition is a fundamental ecophysiological response that serves as a scientific model for environmental signal integration and is pivotal for industrial fermentations of Bacillus that occur predominantly under nutrient starvation.
Keywords: Glucose starvation, Transcriptomics, Proteomics, Metabolomics,Bacillus subtilis,
Submitter: Praveen kumar Sappa
Studies: B. subtilis Transcription Factor Competition, Batchfermentation exp-starv01_090204, Biphase Batch Fermentation(2009/02/04), Controlled sigmaB induction in shake flask, Transition to starvation in shake flask
Assays: 2D-gelbased analysis of intracellular proteins, Absolute quantification of proteins by the AQUA-technology, B. subtilis Transcription Factor Competition - theoretical interpretation, B. subtilis Transcription Factor Competition - theoretical interpretation, Fermentation-BM5_SysMo, Gene expression(Transcriptome), IPTG induction of sigmaB in BSA115, IPTG induction of sigmaB in BSA115, Relative quantification of proteins by metabolic labeling, Stressosome activation dynamics, metabolome-LCMS
Tool and work flow development for computational biology.
Cellular parameters of strains lacking both TRK1 and TRK2 genes.
Submitter: Falko Krause
Studies: Bioinformatic studies, Current-voltage relation, Genetic analysis, Key Cell-Physiological Parameters of TRK1,2 Transport Systems Investiga..., Kinetic properties of Trk, Promotor Anaysis, Proteomic analysis, Transcriptional Profile, Transcriptomic Profiling of 14-3-3 Mutants
Assays: 2D Gel Analysis, Current voltage relation for different external KCl, Current-voltage relation for different internal potassium, Describing of membrane potential changes in response to proton fluxes., Determination of kinetic properties based on MIFE flux data and measurem..., In silico Promotor Anaysis, Insilico Promotor Anaysis, Interaction Database Analysis, Internal pH, Membrane Potential, Modelling of the Trk-current, Potassium Concentration, Protein Concentration, Volume
Collection of models submitted to PLaSMo by Carl Troein and automatically transferred to FAIRDOM Hub.
Submitter: BioData SynthSys
Studies: T2011 Ostreococcus clock, CCA1 degr D - PLM_86, T2011 Ostreococcus clock, CCA1 degr L - PLM_85, T2011 Ostreococcus clock, CCA1 prod D - PLM_88, T2011 Ostreococcus clock, CCA1 prod L - PLM_87, T2011 Ostreococcus clock, TOC1 act D - PLM_92, T2011 Ostreococcus clock, TOC1 act L - PLM_91, T2011 Ostreococcus clock, TOC1 degr D - PLM_90, T2011 Ostreococcus clock, TOC1 degr L - PLM_89, T2011 Ostreococcus clock, acc immediate - PLM_83, T2011 Ostreococcus clock, acc on - PLM_84, Troein Ostreococcus clock 1-loop - PLM_7
Assays: T2011 Ostreococcus clock, CCA1 degr D - PLM_86, version 1, T2011 Ostreococcus clock, CCA1 degr L - PLM_85, version 1, T2011 Ostreococcus clock, CCA1 prod D - PLM_88, version 1, T2011 Ostreococcus clock, CCA1 prod L - PLM_87, version 1, T2011 Ostreococcus clock, TOC1 act D - PLM_92, version 1, T2011 Ostreococcus clock, TOC1 act L - PLM_91, version 1, T2011 Ostreococcus clock, TOC1 degr D - PLM_90, version 1, T2011 Ostreococcus clock, TOC1 degr L - PLM_89, version 1, T2011 Ostreococcus clock, TOC1 degr L - PLM_89, version 2, T2011 Ostreococcus clock, acc immediate - PLM_83, version 1, T2011 Ostreococcus clock, acc on - PLM_84, version 1, Troein Ostreococcus clock 1-loop - PLM_7, version 1, Troein Ostreococcus clock 1-loop - PLM_7, version 2