Investigations

What is an Investigation?
173 Investigations visible to you, out of a total of 533

Aim: To provide quantitative data that will allow modeling of gene expression for all enzymes of redox metabolism and the pentose phosphate pathway. Modeling will be used to predict enzyme levels based on the integration of an RNA degradation model with translation and protein degradation rates.

Plan: The amounts of a protein in a cell can be determined by the rates of transcription, mRNA processing, translation, mRNA turnover and protein degradation. In trypanosomes analysis is simpler because ...

methods developed during COSMIC

The investigation entails the construction and validation of a detailed mathematical model for glycolysis erythrocytes infected with the malaria parasite Plasmodium falciparum in the blood stage form.

The investigation entails the construction and validation of a detailed mathematical model for glycolysis of the malaria parasite Plasmodium falciparum in the blood stage trophozoite form.

We performed topological analysis on pathways from a harmonised dataset containing pathways from the COVID-19 Disease Map, WikiPathways, and Reactome. The analysis was done using Vanted, SBGN-ED, and LMME which support the import and export of several standard formats (such as SBML, and SBGN-ML).

Collection of models submitted to PLaSMo by Maria-Luisa Guerriero and automatically transferred to FAIRDOM Hub.

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